Modeling studies on the role of vitamins B1 (thiamin), B3 (nicotinamide), B6 (pyridoxamine), and caffeine as potential leads for the drug design against COVID-19Article Published on 2022-11-072022-11-15 Journal: Journal of molecular modeling [Category] SARS, 신약개발, 치료제, [키워드] ACE-2 adopted Antiviral antiviral activity applied approach binding pocket binding site caffeine Cell Characteristics chemical property Compound COVID-19 COVID-19 pandemic docking domain dosage drug design effective evaluate function impair Interaction Invasion lack mechanism modeling molecular molecular dynamic simulations Neutral nicotinamide potential mechanism Protein pyridoxamine Safe SARS-CoV-2 selected Side effects Structural analysis Structure the SARS-CoV-2 the Spike thiamin Toxicity Vitamin Vitamin B. [DOI] 10.1007/s00894-022-05356-9 PMC 바로가기
Identification of mutations in SARS-CoV-2 PCR primer regionsArticle Published on 2022-11-042022-11-15 Journal: Scientific Reports [Category] SARS, 변종, 치료기술, 치료제, [키워드] Accuracy Analysis anticipated approach dataset diagnostic Efficiency genomic variation gold standard identification Mutation Neutral omicron overlapping PCR PCR efficiency primer primer set primer sets Region RT-PCR Sample SARS-CoV-2 SARS-CoV-2 PCR SARS-CoV-2 viral strain susceptible target region the SARS-CoV-2 genome variant Variation [DOI] 10.1038/s41598-022-21953-3 PMC 바로가기
In silico characterization of mutations circulating in SARS-CoV-2 structural proteinsArticle Published on 2022-11-012022-11-16 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 변종, [키워드] Algorithm Analysis caused circulating computational approach computational tool COVID-19 D614G death Deleterious discrete molecular dynamics DMD envelope protein full-length identify infections meta-data molecular molecular simulations mutant Mutation mutations N protein Neutral NMA non-structural protein normal mode analysis Nsp3 nucleocapsid nucleocapsid protein pandemic predicted Protein protein coding gene protein stability Proteins RdRP RNA-directed RNA polymerase SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes sequence Seven Spike protein stability structural protein suggested utilised viral dynamics viral genome viral pathogenicity Viral pathogenicity. [DOI] 10.1080/07391102.2021.1908170 PMC 바로가기
Insertion/deletion hotspots in the Nsp2, Nsp3, S1, and ORF8 genes of SARS-related coronavirusesArticle Published on 2022-10-282022-11-16 Journal: BMC Ecology and Evolution [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome animal hosts base bases bat bat coronavirus benefit Characteristics classical complex coronavirus determine Frame Future Genome genomic region hotspot Human human SARS-CoV-2 human SARS-CoV-2 strain INDEL Indel hotspot indels insertion/deletion insertion/deletion (indel). mechanism Multiple sequence alignment Mutation N-terminal domain Neutral non-structural protein Occurrence offer ORF8 ORF8 gene pangolin Pangolin coronavirus (PCoV) Point mutation RaTG13 Region reported RNA sequence S1 domain SARS-CoV SARS-CoV-2 SARS-related coronavirus SARS-related coronaviruses severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) survival the spike protein viral evolution virus virus viruses [DOI] 10.1186/s12862-022-02078-7 PMC 바로가기
Time Series Analysis of SARS-CoV-2 Genomes and Correlations among Highly Prevalent MutationsArticle Published on 2022-10-262022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome Analysis arising caused characterized Cluster Clustering computational tool contribute coronavirus correlated correlation correlation coefficient COVID-19 Deleterious Effect effort Evolution Frequency Genome genomes Hierarchical hierarchical clustering identify imperative in viral Meta-analysis Mutation mutations negative correlation Neutral NSP2 Nsp3 nucleotide ORF3a protein P323L pandemic Pearson Pearson correlation performed positive Protein protein dynamics. Q57H RdRP replaced RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome SARS-CoV-2 genomic sequence SARS-CoV-2 isolate SARS-CoV-2 sequences Scientific community Sery shown similarity stabilizing effect statistical T85I These data time UTR viral evolution viral genomes viral pathogenesis viral replication viral strains wild type wild-type [DOI] 10.1128/spectrum.01219-22 PMC 바로가기
Emotions and Topics Expressed on Twitter During the COVID-19 Pandemic in the United Kingdom: Comparative Geolocation and Text Mining AnalysisArticle Published on 2022-10-052022-11-16 Journal: Journal of Medical Internet Research [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Analysis approach can be used change changed Comparative conditions COVID-19 COVID-19 pandemic declined deep learning deep learning-based method dominant emotion emotion detection epidemiological epidemiological situation Express expressing expression geolocation Government Health increase in measure natural language processing negative emotion Neutral omicron optimism outbreak over pandemic platform positive positive attitude Positive emotion proportion public health sentiment analysis social media text text mining the epidemic thought Topic topic modeling. Twitter United Kingdom vaccination variant [DOI] 10.2196/40323 PMC 바로가기
Contrasting Patterns in the Early Stage of SARS-CoV-2 Evolution between Humans and MinksArticle Published on 2022-09-012022-11-16 Journal: Molecular Biology and Evolution [Category] SARS, 변종, [키워드] adaptive amino acid changes analyzed change circulating deviate domain early phase Epidemic Epidemics Evolution feature Frequency Genetic genetic hitchhiking Host Human humans Infection Ka/Ks lack late phase mink Mutation mutations Neutral nonsynonymous other coronaviruses outbreak pandemic parental pattern positive Positive selection produced receptor-binding motif SARS-CoV SARS-CoV-2 selection process sequence site frequency spectrum site frequency spectrum. Stage Strong synonymous the SARS-CoV-2 the spike protein unique variant virus virus [DOI] 10.1093/molbev/msac156 PMC 바로가기
Remdesivir for the treatment of COVID-19: a systematic review and meta-analysisReview article Published on 2022-09-012022-10-05 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 임상, 치료법, [키워드] 95% CI assessment Bayesian benefit clinically conducted coronavirus COVID-19 criteria eight eligibility criteria evaluate Hospitalized hospitalized patient Inpatient mechanical ventilation Meta-analysis Mortality Neutral objective oxygen Oxygen requirements participant Participants Patient patients with COVID-19 performed Placebo Primary outcome Probability random effect randomized trials recommendation reduce reduced Remdesivir requiring supplemental oxygen Result risk risk of bia risk reduction searched Standard of care stratified supplemental oxygen systematic review the patient therapy Treatment with COVID-19 World Health Organization [DOI] 10.1016/j.cmi.2022.04.018 [Article Type] Review article
AI-based search for convergently expanding, advantageous mutations in SARS-CoV-2 by focusing on oligonucleotide frequenciesArticle Published on 2022-08-312022-11-16 Journal: PLoS ONE [Category] SARS, 변종, [키워드] amino acids candidate changes in expand Focusing Frequency function identify involved Lineage lineages MOST Mutation mutations Neutral occur omicron phylogenetically SARS-CoV-2 SARS-CoV-2 genome sequence Transmission viral genome viral replication virus [DOI] 10.1371/journal.pone.0273860 PMC 바로가기
Mechanistic insights into global suppressors of protein folding defectsArticle Published on 2022-08-292022-11-16 Journal: PLoS Genetics [Category] SARS, 변종, 유전자 메커니즘, [키워드] accelerate aggregation amino acid substitution bacterial toxin caused characterized Combination crystal structure driver Effects ENhance Evolution examined facilitate functional protein in vitro in vivo inactive increase in Isolation loss-of-function loss-of-function mutations mechanism molecular interaction MOST mutants Mutation Neutral observé parameter Phenotypes promote Protein responsible shown stability suppressor suppressor mutation the SARS-CoV-2 thermodynamic while wildtype [DOI] 10.1371/journal.pgen.1010334 PMC 바로가기